.NET Framework 4.8 receives monthly security and reliability updates via Windows Update (part of the monthly rollup). No separate servicing needed. The Ultimate Guide to
You need cross-platform support, significant performance improvements for server workloads, smaller deployments, or modern language/runtime features.
You are starting a new application where future portability and lightweight hosting (containers) matter.
You want access to the latest APIs, improved GC/throughput optimizations, and active feature development.