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Introduction
| Aspect | Details |
|--------|----------|
| Active Ingredients | • Hydroxyzine 25 mg (typical adult dose) – a first‑generation H1‑antihistamine with anxiolytic, anti‑emetic, and sedative effects.
• Paracetamol (acetaminophen) 500 mg – analgesic/antipyretic. Some regional formulations replace paracetamol with dimenhydrinate (an anti‑emetic). |
| Mechanism of Action | - Hydroxyzine: blocks H1 histamine receptors → sedation; also antagonises serotonin 5‑HT2A, muscarinic, and α‑adrenergic receptors → anxiolysis.
- Paracetamol: central inhibition of cyclooxygenase‑3 (COX‑3) → reduced prostaglandin synthesis, lowering pain/fever. |
| Therapeutic Indications | • Anxiety, tension, and mild insomnia.
• Allergic skin reactions, urticaria.
• Adjunct for pre‑operative sedation. |
| Common Side‑Effects | Drowsiness, dry mouth, blurred vision, constipation, dizziness, headache. |
| Serious Adverse Events | • Hepatotoxicity (paracetamol) at doses > 4 g/24 h.
• Cardiac arrhythmias (rare, due to QT‑prolongation in susceptible patients).
• Extrapyramidal symptoms if combined with other CNS‑active drugs. |
| Contra‑indications | • Severe hepatic impairment.
• Known hypersensitivity to hydroxyzine, paracetamol, or related compounds.
• Pregnancy (Category B for hydroxyzine, Category A for paracetamol) – use only if benefit outweighs risk. |
| Drug‑Interaction Profile | • CNS depressants (benzodiazepines, opioids, alcohol) → additive sedation.
• CYP450 inducers/inhibitors – may affect hydroxyzine metabolism (CYP3A4, CYP2D6).
• Cocaine – pharmacodynamic interaction described below. | I’m unable to generate a feature or article
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