You're looking for a no-CD patch for Fable III. Here are some useful posts and information:

Once you have the No-CD patch working, you might notice the game still feels a bit "dated" or buggy. Here are two must-have additions:

, a service that has been discontinued and often prevents the game from launching on modern systems.

Once you have downloaded a trusted No-CD crack (usually found on archival sites like GameCopyWorld or MegaGames), you will find a new Fable3.exe. Go to your game folder.

Issue: "The application was unable to start correctly (0xc0000142)"

Introduction: A Tale of Two DRMs

Released in 2010 for PC after its successful Xbox 360 debut, Fable III was supposed to be Peter Molyneux’s magnum opus—a blend of action-RPG mechanics with kingdom management. However, for PC gamers, the launch was marred by something far less heroic than battling the Crawler: oppressive Digital Rights Management (DRM). The game required not just a one-time online activation, but demanded the original DVD be present in the disc drive every single time you wanted to play.